Applying solitary-molecule optical and AFM imaging and power-spectroscopy methods, we seek to unravel the mechanistic components of the framework and dynamics of chromosomes. Our analysis interests involve:

Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules

Dynamics of initiation, termination and reinitiation of DNA translocation via the motor protein EcoR124I

Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on solitary molecules and steel clusters

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Direct immobilization of indigenous yeast iso-1 cytochrome c on bare gold: speedy electron relay to redox enzymes and zeptomole protein-film voltammetry

Length control of particular person carbon nanotubes by nanostructuring with the scanning tunneling microscope

2011, initially in vitro measurements of transportation across just one biomimetic nuclear pore complicated; improvement of ceesdekker multiplexed magnetic tweezers for kilo-molecule experiments; and settled the mechanism of homology recognition in DNA homologous recombination

‘You shouldn't just think about the questions of tomorrow, but additionally think about the concerns from the day after tomorrow’

Resolving the step size in condensin-pushed DNA loop extrusion identifies ATP binding given that the move-building system

Tests pseudotopological and nontopological designs for SMC-pushed DNA loop extrusion against roadblock-traversal experiments

Nature Physics thanks the nameless reviewers for his or her contribution to your peer critique of the do the job.

Developments in nanotechnology while in the 1990s made developing electronic devices from solitary molecules a chance. Cees Dekker recounts how his team created a home-temperature transistor based on a single carbon nanotube.

 Lastly, I will briefly sketch many of our Strategies to check out the creating of synthetic cells, precisely our initially methods to ascertain artificial mobile division.